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PX1 Labs KPV 10 mg research peptide vial
Skin & Recovery

KPV

Anti-inflammatory tripeptide for gut and skin · 500 mcg/day · 4–8 weeks

Lys-Pro-Val · alpha-MSH tripeptide fragment

An anti-inflammatory tripeptide — the calming piece inside the KLOW blend, associated with gut and skin inflammation.

€34.9910 mg · LyophilizedIn stock
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Purity 99%+ HPLC
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Documentation CoA included

For laboratory and in vitro research use only. Not for human or veterinary use, and not for use in diagnostic procedures.

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ClassAnti-inflammatory tripeptide (alpha-MSH fragment)
Half-lifeHours
Typical routeSubQ / oral
Cycle4–8 weeks
CategorySkin & Recovery
Price€34.99
🧾 View Certificate of Analysis

About KPV

KPV is a three-amino-acid fragment (lysine-proline-valine) of the natural anti-inflammatory hormone alpha-MSH. It is associated with switching off inflammatory signalling (NF-κB) before it starts, while leaving normal immune function intact — which is why it features in gut and reactive-skin discussion.

PX1 Labs supplies KPV as a 10 mg lyophilized powder verified at 99%+ identity purity by HPLC, with identity confirmed by mass spectrometry. A lot-specific Certificate of Analysis is included with every order.

What it's known for

KPV is best known for inflammation — gut and skin. Here is what it is most associated with. (Supplied for laboratory research use only.)

Inflammation

Best known as an anti-inflammatory peptide that pre-empts the inflammation switch (NF-κB).

Gut

Its strongest research signal is gut inflammation, where inflamed cells actively take it up.

Skin

The calming component in skin blends like KLOW, for reactive or red skin.

What research shows

Mechanistic and small-trial data (gut, skin); no large subcutaneous human trials.

How it works

KPV is a three-amino-acid fragment of alpha-MSH, a natural anti-inflammatory hormone. It is associated with blocking inflammatory genes (NF-κB) from switching on in the first place — different from drugs that block inflammation after it starts — while leaving normal immune signalling intact.

What the evidence shows

KPV's strongest evidence is mechanistic and from small trials, especially for gut inflammation (where inflamed cells actively absorb it) and topical/skin use. There is no large subcutaneous human trial. Not an approved medicine.

An educational summary, not a treatment claim or medical advice.

Side effects & safety
Reference information — not medical adviceSummarised from public research literature. PX1 Labs products are supplied for laboratory research use only; not for human or veterinary use.

Commonly reported

  • Generally well tolerated in studies
  • Mild injection-site or GI irritation
  • Occasional headache

Cautions & contraindications

  • Human data is limited (mostly preclinical / small studies)
  • Derived from alpha-MSH but without pigmentation effects
  • Avoid in pregnancy/breastfeeding
Dosage chart (reference only)
Commonly cited ranges — not a recommendationBeginner / standard / advanced figures collected from public, widely available community references. Provided for reference and comparison only — not a dosing instruction or medical advice. Supplied for laboratory research use only.
BeginnerStandardAdvanced
200 mcg/day500 mcg/day1 mg/day
Frequency1× daily
TimingMorning
Cycle length4–8 weeks
Typical routeSubQ / oral

Convert any dose to a syringe draw →

Reference protocols
Reference only — not a recommendationThe figures below are commonly cited in public and community references. They are provided for reference and comparison only — not a dosing instruction, recommendation, or medical advice. PX1 Labs products are supplied for laboratory research use only; not for human or veterinary use.
ContextCommonly cited amountFrequency
Commonly cited200–500 mcg1× daily

Reconstitution example: e.g. 10 mg + 2 mL → 5 mg/mL; 250 mcg = 0.05 mL (5 units).

Often used in short courses; oral forms are also referenced for gut-specific use.

Work out your own draw in the calculator →

What researchers commonly report — by week
Commonly reported, not guaranteedThese timelines summarise what self-experimenters and widely available community sources describe. Individual results vary widely, many notice nothing on this schedule, and these are not promised outcomes. Reference information only — not medical advice. PX1 Labs products are supplied for laboratory research use only.
Week 1–2
Easing of gut or skin inflammation commonly reported.
Week 3–4
More consistent calming of flare-ups noted.
Ongoing
Often short courses; oral forms cited for gut focus.

Specifications

Every PX1 Labs lot is independently verified before dispatch. The figures below describe the product class; exact lot-specific results are documented on the Certificate of Analysis included with your order.

Compound classAnti-inflammatory tripeptide (alpha-MSH fragment)
CAS number67727-97-3
Molecular formulaC₁₆H₃₀N₄O₃
Molecular weight≈ 342.4 g/mol
Identity purity99%+ (HPLC)
Identity confirmationMass spectrometry
Presentation10 mg lyophilized powder
Physical formSterile-filtered, freeze-dried
Storage2-8°C; -20°C long term
DocumentationLot-specific Certificate of Analysis

Documentation & quality

KPV passes the same five-stage PX1 quality process applied to every product: HPLC potency analysis, mass-spectrometry identity and purity confirmation, pH and stability validation, sterility and endotoxin (LAL) testing, and QC batch-consistency verification.

A lot-specific Certificate of Analysis ships with every order. The lot number printed on your vial matches the lot ID on the document, so the material on your bench can always be checked against the data on file.

References & research

Selected peer-reviewed literature on KPV (via PubMed), provided for educational context. A reference does not imply a clinical claim for PX1 Labs products.

  1. Anti-inflammatory effects of alpha-MSH-related peptides beyond the pharmacophore.
  2. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-MSH peptides.
  3. alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.

KPV — questions

What is KPV?

A tripeptide fragment of alpha-MSH (Lys-Pro-Val), known as an anti-inflammatory peptide. It is the KPV in the KLOW blend.

How is KPV supplied?

As a 10 mg lyophilized powder with a lot-specific Certificate of Analysis confirming 99%+ identity purity by HPLC.

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